7-(2) (Supplementary) Additional Discussion

Additional file 2 — Supplementary figures and tables

1Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland 2Institute of Socialand Preventive Medicine, University of Zurich, Hirschengraben 84, CH-8001 Zurich, Switzerland 3Department of Mathematical Sciences, Norwegian University of Science and Technology, N-7491 Trondheim, Norway 4Institute of Molecular Cancer Research, University of Zur...

Supplementary results and discussion

Role of receptor internalization. Comparing the kinetics of activation of the different signaling molecules, it can be seen that the majority of the signal results from the receptors at the plasma membrane at the EGF concentration of 50 ng/ml. The phosphorylation and association of phosphorylated Shc to receptors, which are still at the surface, is so fast that Ras-GTP activation has already pe...

Additional Results and Discussion

The WT-V129_1 asymmetric unit contains one PrP molecule, exhibiting the conserved PrP fold. The C-terminal helix 3 is 3D-domain swapped with a second molecule related by crystallographic two-fold symmetry (Figure 1A), resulting in a dimer covalently-linked by disulfide bonds that is nearly identical to the WT-M129 structure (Knaus et al, 2001). A threonine-rich hinge loop (T190-F198) precedes h...

7. Discussion

In this paper we have investigated ways to incorporate both internal and external nonde-terministic actions in a system that formalizes the reasoning of agents on their abilities and the eeects of the actions that they perform. To this end we deened the notions of-nite computation sequences and nite computation runs: these are nite strings of atomic actions and tests. The results that we obtain...

7 General Discussion